EndOclear Study

The goal of this study is to evaluate the clinical benefits of the endOclear device in keeping endotracheal tubes (ETT) free from secretions and bacterial colonization from the moment of the intubation. The study hypothesizes that the routine use of endOclear from the time of intubation (time 0) in patients expected to remain intubated for more than 48 hours with a standard ETT could be more effective than the standard suctioning alone to maintain ETT lumen patency, reducing ETT colonization and biofilm formation.

Publication: 

Endotracheal Tubes Cleaned With a Novel Mechanism for Secretion Removal: A Randomized Controlled Clinical Study

Pinciroli R, Mietto C, Piriyapatsom A, Chenelle CT, Thomas JG, Pirrone M1, Bry L, Wojtkiewicz GR, Nahrendorf MP, Kacmarek RM, Berra L.

Services provided: Microbiologic analyses assessed materials from the extubated endotracheal tubes. Samples were plated to standard media for work-up of respiratory specimens. Plates were read by MHMC Clinical Microbiologists who provided an overall biomass in CFU/mL and speciated potential bacterial and fungal pathogens. Antimicrobial susceptibility testing of spectated isolates further identified potential drug-resistant strains.

EndOclear Study Project Services and Costs

DescriptionQuantityUnitsHDDCInternalAcademicCommercial
Total Project Cost**27,778.2746,240.3366,583.3787,570.67
Project Setup1each175.63295.95426.17564.68
Consulting Fees-Project Management3hour143.28241.44347.67460.67
Anaerobic Culture Complex Quantitative Analysis50per unit71.22120.02172.83229
Aerobic Culture Complex-Quantitative Plating, Gram Stain & Analysis at 3 Units Per Sample99per unit32.654.9479.11104.82
Aerobic Culture Complex-Quantitative Plating, Gram Stain & Analysis at 2.5 Units Per Sample250per unit32.654.9479.11104.82
Aerobic Culture Complex-Quantitative Plating, Gram Stain & Analysis at 2 Units Per Sample38per unit32.654.9479.11104.82
Aerobic Culture- ID 2-5 Isolates at 2 Units62per unit32.654.9479.11104.82
Aerobic Culture-ID 1 Isolate at 1 Unit40per unit32.654.9479.11104.82
Susceptibility Testing at 2 Units Per Sample142per unit32.654.9479.11104.82
Susceptibility Testing at 1 Unit Per Sample8per unit32.654.9479.11104.82
Other Micro Support-Process & Analyze 5 Isolates in 2 Conditions at 3 Timepoints60per unit46.3468.5498.69119.9
*FY 2018 Fees
**Approximate cumulative costs reflected over a three year study period