The goal of this study is to evaluate the clinical benefits of the endOclear device in keeping endotracheal tubes (ETT) free from secretions and bacterial colonization from the moment of the intubation. The study hypothesizes that the routine use of endOclear from the time of intubation (time 0) in patients expected to remain intubated for more than 48 hours with a standard ETT could be more effective than the standard suctioning alone to maintain ETT lumen patency, reducing ETT colonization and biofilm formation.
Publications:
Endotracheal Tubes Cleaned With a Novel Mechanism for Secretion Removal: A Randomized Controlled Clinical Study
Pinciroli R, Mietto C, Piriyapatsom A, Chenelle CT, Thomas JG, Pirrone M1, Bry L, Wojtkiewicz GR, Nahrendorf MP, Kacmarek RM, Berra L.
Tracheal tube obstruction in mechanically ventilated patients assessed by high-resolution computed tomography.
Mietto C, Pinciroli R, Piriyapatsom A, Thomas JG, Bry L, Delaney ML, Dubois A, Truelove J, Ackman JB, Wojtkiewicz GR, Nahrendorf MP, Kacmarek RM, Berra L.
Services provided: Microbiologic analyses assessed materials from the extubated endotracheal tubes. Samples were plated to standard media for work-up of respiratory specimens. Plates were read by MHMC Clinical Microbiologists who provided an overall biomass in CFU/mL and speciated potential bacterial and fungal pathogens. Antimicrobial susceptibility testing of spectated isolates further identified potential drug-resistant strains.
EndOclear Study Project Services and Costs
| Description | Quantity | Units | HDDC | Internal | Academic | Commercial |
|---|---|---|---|---|---|---|
| Project Setup | 1 | each | 175.63 | 295.95 | 426.17 | 564.68 |
| Consulting Fees-Project Management | 3 | hour | 143.28 | 241.44 | 347.67 | 460.67 |
| Anaerobic Culture Complex Quantitative Analysis | 50 | per unit | 71.22 | 120.02 | 172.83 | 229 |
| Aerobic Culture Complex-Quantitative Plating, Gram Stain & Analysis at 3 Units Per Sample | 99 | per unit | 32.6 | 54.94 | 79.11 | 104.82 |
| Aerobic Culture Complex-Quantitative Plating, Gram Stain & Analysis at 2.5 Units Per Sample | 250 | per unit | 32.6 | 54.94 | 79.11 | 104.82 |
| Aerobic Culture Complex-Quantitative Plating, Gram Stain & Analysis at 2 Units Per Sample | 38 | per unit | 32.6 | 54.94 | 79.11 | 104.82 |
| Aerobic Culture- ID 2-5 Isolates at 2 Units | 62 | per unit | 32.6 | 54.94 | 79.11 | 104.82 |
| Aerobic Culture-ID 1 Isolate at 1 Unit | 40 | per unit | 32.6 | 54.94 | 79.11 | 104.82 |
| Susceptibility Testing at 2 Units Per Sample | 142 | per unit | 32.6 | 54.94 | 79.11 | 104.82 |
| Susceptibility Testing at 1 Unit Per Sample | 8 | per unit | 32.6 | 54.94 | 79.11 | 104.82 |
| Other Micro Support-Process & Analyze 5 Isolates in 2 Conditions at 3 Timepoints | 60 | per unit | 46.34 | 68.54 | 98.69 | 119.9 |
| Total Project Cost** | 27,778.27 | 46,240.33 | 66,583.37 | 87,570.67 |
**Approximate cumulative costs reflected over a three year study period